产品名称
CLP36 Rabbit Polyclonal Antibody
别名
PDLIM1; CLIM1; CLP36; PDZ and LIM domain protein 1; C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36
蛋白名称
PDZ and LIM domain protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9124
Human Swissprot No.
O00151
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O00151/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54132
Mouse Swissprot No.
O70400
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70400
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54133
Rat Swissprot Link
http://www.uniprot.org/uniprot/P52944
免疫原
The antiserum was produced against synthesized peptide derived from human PDLIM1. AA range:61-110
特异性
CLP36 Polyclonal Antibody detects endogenous levels of CLP36 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012],
组织表达
Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Associates with actin stress fibers. .
功能
function:Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Associates with the actin stress fibers.,subunit:Interacts with alpha-actinins 1, 2 and 4.,tissue specificity:Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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