BD-PN3334

PIWL2 Rabbit Polyclonal Antibody

Piwi-like protein 2 (Cancer/testis antigen 80) (CT80)

常规抗体

PIWIL2 HILI

PIWL2

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.292% New type preservative N.

55124

https://www.uniprot.org/uniprot/55124

Q8TC59

https://www.uniprot.org/uniprotkb/Q8TC59/entry

57746

https://www.uniprot.org/uniprot/57746

Q8CDG1

https://www.uniprot.org/uniprotkb/Q8CDG1

Synthesized peptide derived from human PIWL2 AA range: 754-804

This antibody detects endogenous levels of PIWL2 at Human/Mouse

WB 1:500-2000

105kD

-20°C/1 year

Polyclonal, Rabbit,IgG

PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008],

Expressed in adult testis and in most tumors.

Cytoplasm . Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. .

catalytic activity:3-beta-hydroxy-Delta(5)-steroid + NAD(+) = 3-oxo-Delta(5)-steroid + NADH.,catalytic activity:Cholest-5-ene-3-beta,7-alpha-diol + NAD(+) = 7-alpha-hydroxycholest-4-en-3-one + NADH.,disease:Defects in HSD3B7 are the cause of congenital bile acid synthesis defect type 1 (CBAS1) [MIM:607765]; also known as neonatal progressive intrahepatic cholestasis. CBAS1 is due to a primary defect in bile synthesis leading to progressive liver disease. Clinical features include neonatal jaundice, severe intrahepatic cholestasis and cirrhosis.,function:Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate to similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates to a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.,function:The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.,pathway:Lipid metabolism; steroid biosynthesis.,sequence caution:Translated as Arg.,similarity:Belongs to the 3-beta-HSD family.,similarity:Belongs to the argonaute family. Piwi subfamily.,similarity:Contains 1 PAZ domain.,similarity:Contains 1 Piwi domain.,subcellular location:Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis.,subunit:Interacts with DDX4, MAEL, EIF3A, EIF4E and EIF4G. Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes.,tissue specificity:Expressed in adult testis and in most tumors.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.