产品名称
CLIP-170 Rabbit Polyclonal Antibody
别名
CLIP1; CYLN1; RSN; CAP-Gly domain-containing linker protein 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; CLIP-170; Reed-Sternberg intermediate filament-associated protein; Restin
蛋白名称
CAP-Gly domain-containing linker protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6249
Human Swissprot No.
P30622
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30622/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56430
Mouse Swissprot No.
Q922J3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q922J3
免疫原
The antiserum was produced against synthesized peptide derived from human CLIP1. AA range:1291-1340
特异性
CLIP-170 Polyclonal Antibody detects endogenous levels of CLIP-170 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
组织表达
Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle . Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). .
信号通路
Regulation of Microtubule Dynamics
功能
function:Seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.,similarity:Contains 2 CAP-Gly domains.,subcellular location:Associated with the cytoskeleton.,tissue specificity:Highly expressed in the Reed-Sternberg cells of Hodgkin's disease.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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