产品名称
CLIP-115 Rabbit Polyclonal Antibody
别名
CLIP2; CYLN2; KIAA0291; WBSCR3; WBSCR4; WSCR4; CAP-Gly domain-containing linker protein 2; Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndro
蛋白名称
CAP-Gly domain-containing linker protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7461
Human Swissprot No.
Q9UDT6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UDT6/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=269713
Mouse Swissprot No.
Q9Z0H8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z0H8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29264
Rat Swissprot Link
http://www.uniprot.org/uniprot/O55156
免疫原
The antiserum was produced against synthesized peptide derived from human CLIP2. AA range:997-1046
特异性
CLIP-115 Polyclonal Antibody detects endogenous levels of CLIP-115 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008],
组织表达
Brain,Clones donated by Kazusa DNA Research Inst.,Epitheliu
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Localizes preferentially to the ends of tyrosinated microtubules. .
信号通路
Regulation of Microtubule Dynamics
功能
disease:Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operates in the control of brain-specific organelle translocations.,similarity:Contains 2 CAP-Gly domains.,subcellular location:Associated with the cytoskeleton.,subunit:Interacts with CLASP1 and CLASP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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