产品名称
CLIC6 Rabbit Polyclonal Antibody
别名
CLIC6; CLIC1L; Chloride intracellular channel protein 6; Parchorin
蛋白名称
Chloride intracellular channel protein 6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54102
Human Swissprot No.
Q96NY7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96NY7/entry
Mouse Swissprot No.
Q8BHB9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BHB9
免疫原
The antiserum was produced against synthesized peptide derived from human CLIC6. AA range:411-460
特异性
CLIC6 Polyclonal Antibody detects endogenous levels of CLIC6 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
chloride intracellular channel 6(CLIC6) Homo sapiens This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015],
组织表达
Expressed in brain, placenta, pancreas and liver.
细胞定位
Cytoplasm . Cell membrane ; Single-pass membrane protein . Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). .
功能
domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.,function:May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.,PTM:Phosphorylated.,similarity:Belongs to the chloride channel CLIC family.,similarity:Contains 1 GST C-terminal domain.,subcellular location:Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane.,subunit:Interacts with dopamine receptors DRD2, DRD3 and DRD4.,tissue specificity:Expressed in brain, placenta, pancreas and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
