产品名称
CLIC3 Rabbit Polyclonal Antibody
别名
CLIC3; Chloride intracellular channel protein 3
蛋白名称
Chloride intracellular channel protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9022
Human Swissprot No.
O95833
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95833/entry
Mouse Swissprot No.
Q9D7P7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D7P7
免疫原
The antiserum was produced against synthesized peptide derived from human CLIC3. AA range:21-70
特异性
CLIC3 Polyclonal Antibody detects endogenous levels of CLIC3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
chloride intracellular channel 3(CLIC3) Homo sapiens Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008],
组织表达
Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.
细胞定位
Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). .
功能
domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.,function:Can insert into membranes and form chloride ion channels. May participate in cellular growth control.,similarity:Belongs to the chloride channel CLIC family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subcellular location:Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.,subunit:Associated with the C-terminal of ERK7.,tissue specificity:Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
