产品名称
CLC-KA Rabbit Polyclonal Antibody
别名
CLCNKA; Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1
蛋白名称
Chloride channel protein ClC-Ka
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1187
Human Swissprot No.
P51800
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51800/entry
Mouse Swissprot No.
Q9WUB7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WUB7
免疫原
The antiserum was produced against synthesized peptide derived from human CLCNKA. AA range:581-630
特异性
CLC-KA Polyclonal Antibody detects endogenous levels of CLC-KA protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
细胞定位
Membrane; Multi-pass membrane protein.
功能
function:Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.,similarity:Belongs to the chloride channel (TC 2.A.49) family.,similarity:Contains 2 CBS domains.,subunit:Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle.,tissue specificity:Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proreins.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
