产品名称
TRPC5 Rabbit Polyclonal Antibody
别名
Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.293% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7224
Human Swissprot No.
Q9UL62
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UL62/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22067
Mouse Swissprot No.
Q9QX29
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QX29
免疫原
Synthesized peptide derived from human TRPC5 AA range: 828-878
特异性
This antibody detects endogenous levels of TRPC5 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010],
组织表达
Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 2 ANK repeats.,subunit:Interacts with NHERF (By similarity). Interacts with MX1 and RNF24.,tissue specificity:Expressed in brain with higher levels in fetal brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
