产品名称
Claudin-6 Rabbit Polyclonal Antibody
别名
CLDN6; Claudin-6; Skullin
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9074
Human Swissprot No.
P56747
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P56747/entry
Mouse Swissprot No.
Q9Z262
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z262
免疫原
The antiserum was produced against synthesized peptide derived from human CLDN6. AA range:81-130
特异性
Claudin-6 Polyclonal Antibody detects endogenous levels of Claudin-6 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010],
组织表达
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
细胞定位
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
信号通路
Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
