产品名称
Claudin-2 Rabbit Polyclonal Antibody
别名
CLDN2; PSEC0059; SP82; Claudin-2; SP82
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9075
Human Swissprot No.
P57739
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P57739/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12738
Mouse Swissprot No.
O88552
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88552
免疫原
The antiserum was produced against synthesized peptide derived from human Claudin 2. AA range:181-230
特异性
Claudin-2 Polyclonal Antibody detects endogenous levels of Claudin-2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],
组织表达
Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,
细胞定位
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
信号通路
Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
