产品名称
Claudin-11 Rabbit Polyclonal Antibody
别名
CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5010
Human Swissprot No.
O75508
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75508/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18417
Mouse Swissprot No.
Q60771
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60771
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q99P82
免疫原
The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207
特异性
Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso
细胞定位
Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
信号通路
Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Interacts with tetraspanin-3/TSPAN3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
