产品名称
Cks1 Rabbit Polyclonal Antibody
别名
CKS1B; CKS1; PNAS-143; PNAS-16; Cyclin-dependent kinases regulatory subunit 1; CKS-1
蛋白名称
Cyclin-dependent kinases regulatory subunit 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1163
Human Swissprot No.
P61024
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P61024/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54124
Mouse Swissprot No.
P61025
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P61025
免疫原
The antiserum was produced against synthesized peptide derived from human CKS1. AA range:10-59
特异性
Cks1 Polyclonal Antibody detects endogenous levels of Cks1 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008],
组织表达
Brain,Muscle,Promyelocytic leukemia,Prostate,Tongue,
细胞定位
cyclin-dependent protein kinase holoenzyme complex,nucleoplasm,SCF ubiquitin ligase complex,
信号通路
Pathways in cancer;Small cell lung cancer;
功能
function:Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.,similarity:Belongs to the CKS family.,subunit:Forms a homohexamer that can probably bind six kinase subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
