产品名称
CHST2 Rabbit Polyclonal Antibody
别名
CHST2; GN6ST; Carbohydrate sulfotransferase 2; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2; GST-2; N-acetylglucosamine 6-O-sulfotransferase 1; GlcNAc6ST-1; Gn6ST-1
蛋白名称
Carbohydrate sulfotransferase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9435
Human Swissprot No.
Q9Y4C5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y4C5/entry
Mouse Swissprot No.
Q80WV3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80WV3
免疫原
The antiserum was produced against synthesized peptide derived from human CHST2. AA range:1-50
特异性
CHST2 Polyclonal Antibody detects endogenous levels of CHST2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011],
组织表达
Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes.
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein .
信号通路
Keratan sulfate biosynthesis;
功能
caution:It is uncertain whether Met-1 or Met-48 is the initiator.,function:Catalyzes the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as L-selectin ligands. L-selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.,induction:Up-regulated upon cytokine activation.,online information:GlycoGene database,similarity:Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.,subunit:Homodimer; disulfide-linked. Homodimerization is not essential for enzyme activity.,tissue specificity:Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
