产品名称
CHST13 Rabbit Polyclonal Antibody
别名
CHST13; Carbohydrate sulfotransferase 13; Chondroitin 4-O-sulfotransferase 3; Chondroitin 4-sulfotransferase 3; C4ST-3; C4ST3
蛋白名称
Carbohydrate sulfotransferase 13
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=166012
Human Swissprot No.
Q8NET6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NET6/entry
免疫原
The antiserum was produced against synthesized peptide derived from human CHST13. AA range:211-260
特异性
CHST13 Polyclonal Antibody detects endogenous levels of CHST13 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011],
组织表达
Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
信号通路
Chondroitin sulfate biosynthesis;Sulfur metabolism;
功能
catalytic activity:3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.,function:Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.,similarity:Belongs to the sulfotransferase 2 family.,tissue specificity:Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
