产品名称
Chr-A Rabbit Polyclonal Antibody
别名
CHGA; Chromogranin-A; CgA; Pituitary secretory protein I; SP-I
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1113
Human Swissprot No.
P10645
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10645/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12652
Mouse Swissprot No.
P26339
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P26339
Rat Swissprot Link
http://www.uniprot.org/uniprot/P10354
免疫原
The antiserum was produced against synthesized peptide derived from human Chr-A. AA range:311-360
特异性
Chr-A Polyclonal Antibody detects endogenous levels of Chr-A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],
组织表达
GE-25 is found in the brain.
细胞定位
[Serpinin]: Secreted . Cytoplasmic vesicle, secretory vesicle . Pyroglutaminated serpinin localizes to secretory vesicle. .; Cytoplasmic vesicle, secretory vesicle . Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle . Secreted . Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules. .
功能
function:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.,miscellaneous:Binds calcium with a low-affinity.,PTM:Sulfated on tyrosine residues and/or contains sulfated glycans.,similarity:Belongs to the chromogranin/secretogranin protein family.,subcellular location:Neuroendocrine and endocrine secretory granules.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
