产品名称
CHP2 Rabbit Polyclonal Antibody
别名
CHP2; HCA520; Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520
蛋白名称
Calcineurin B homologous protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63928
Human Swissprot No.
O43745
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43745/entry
Mouse Swissprot No.
Q9D869
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D869
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=308965
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q810D1
免疫原
The antiserum was produced against synthesized peptide derived from human CHP2. AA range:101-150
特异性
CHP2 Polyclonal Antibody detects endogenous levels of CHP2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013],
组织表达
Expressed in malignantly transformed cells but not detected in normal tissues.
细胞定位
Nucleus . Cytoplasm . Cell membrane . Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Calcium;Oocyte meiosis;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;WNT;WNT-T CELLAxon guidance;VEGF;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;B_Cell_Antigen;Long-term potentiation;Alzheime
功能
function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death.,similarity:Contains 4 EF-hand domains.,subunit:Binds to SLC9A1/NHE1.,tissue specificity:Expressed in malignantly transformed cells but not detected in normal tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
