产品名称
ChoKB Rabbit Polyclonal Antibody
别名
CHKB; CHETK; CHKL; Choline/ethanolamine kinase; Choline kinase beta; CK; CKB; Choline kinase-like protein; Ethanolamine kinase; EK; Ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKB
蛋白名称
Choline/ethanolamine kinase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1120
Human Swissprot No.
Q9Y259
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y259/entry
Mouse Swissprot No.
O55229
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O55229
免疫原
The antiserum was produced against synthesized peptide derived from human CHKB. AA range:301-350
特异性
ChoKB Polyclonal Antibody detects endogenous levels of ChoKB protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009],
组织表达
Brain,Clones donated by RIKEN,Epithelium,Heart,Human lung,Lung,Skeletal muscle,T-ce
信号通路
Fatty acid metabolism;Glycerophospholipid metabolism;PPAR;Adipocytokine;
功能
catalytic activity:ATP + choline = ADP + O-phosphocholine.,catalytic activity:ATP + ethanolamine = ADP + O-phosphoethanolamine.,catalytic activity:Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.,miscellaneous:This protein is produced by a bicistronic gene which also produces the CHKB protein from a non-overlapping reading frame.,miscellaneous:This protein is produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the carnitine/choline acetyltransferase family.,similarity:Belongs to the choline/ethanolamine kinase family.,tissue specificity:Strong expression in heart and skeletal muscle. No expression in liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
