产品名称
Choactase Rabbit Polyclonal Antibody
别名
CHAT; Choline O-acetyltransferase; CHOACTase; ChAT; Choline acetylase
蛋白名称
Choline O-acetyltransferase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1103
Human Swissprot No.
P28329
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P28329/entry
Mouse Swissprot No.
Q03059
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q03059
Rat Swissprot Link
http://www.uniprot.org/uniprot/P32738
免疫原
The antiserum was produced against synthesized peptide derived from human Choactase. AA range:334-383
特异性
Choactase Polyclonal Antibody detects endogenous levels of Choactase protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010],
组织表达
Brain,Lymphocyte,Placenta,Spinal cord,
细胞定位
nucleus,cytoplasm,cytosol,presynapse,
信号通路
Glycerophospholipid metabolism;
功能
catalytic activity:Acetyl-CoA + choline = CoA + O-acetylcholine.,disease:Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.,function:Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.,online information:Choline acetyltransferase entry,similarity:Belongs to the carnitine/choline acetyltransferase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
