产品名称
cGKII Rabbit Polyclonal Antibody
别名
PRKG2; PRKGR2; cGMP-dependent protein kinase 2; cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII
蛋白名称
cGMP-dependent protein kinase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5593
Human Swissprot No.
Q13237
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13237/entry
Mouse Swissprot No.
Q61410
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61410
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25523
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q64595
免疫原
The antiserum was produced against synthesized peptide derived from human PKG2. AA range:92-141
特异性
cGKII Polyclonal Antibody detects endogenous levels of cGKII protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
组织表达
Highly concentrated in brain, lung and intestinal mucosa.
细胞定位
Apical cell membrane ; Lipid-anchor .
信号通路
Gap junction;Long-term depression;Olfactory transduction;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Binding of cGMP results in enzyme activation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,tissue specificity:Highly concentrated in brain, lung and intestinal mucosa.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.