产品名称
c-Fms Rabbit Polyclonal Antibody
别名
CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD antigen CD115
蛋白名称
Macrophage colony-stimulating factor 1 receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1436
Human Swissprot No.
P07333
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P07333/entry
Mouse Swissprot No.
P09581
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P09581
免疫原
The antiserum was produced against synthesized peptide derived from human CSFR. AA range:781-830
特异性
c-Fms Polyclonal Antibody detects endogenous levels of c-Fms protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
组织表达
Expressed in bone marrow and in differentiated blood mononuclear cells.
细胞定位
Cell membrane; Single-pass type I membrane protein.
信号通路
Cytokine-cytokine receptor interaction;Endocytosis;Hematopoietic cell lineage;Pathways in cancer;
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with INPPL1/SHIP2 and THOC5.,tissue specificity:Expressed in bone marrow and in differentiated blood mononuclear cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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