产品名称
Cerebral 1 Rabbit Polyclonal Antibody
别名
RRP8; KIAA0409; NML; hucep-1; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin
蛋白名称
Ribosomal RNA-processing protein 8
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23378
Human Swissprot No.
O43159
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43159/entry
Mouse Swissprot No.
Q9DB85
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DB85
免疫原
The antiserum was produced against synthesized peptide derived from human HUCE1. AA range:271-320
特异性
Cerebral 1 Polyclonal Antibody detects endogenous levels of Cerebral 1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
RRP8 (Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) is a Protein Coding gene. Diseases associated with RRP8 include bowen-conradi syndrome and lymphatic system cancer. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and methylated histone binding. ssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
细胞定位
Nucleus, nucleolus . Localizes at rDNA locus.
功能
rRNA processing,?RNA processing,?rRNA metabolic process,?ribonucleoprotein complex biogenesis,?ncRNA processing,ncRNA metabolic process,?ribosome biogenesis,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
