产品名称
CEP57 Rabbit Polyclonal Antibody
别名
CEP57; KIAA0092; TSP57; Centrosomal protein of 57 kDa; Cep57; FGF2-interacting protein; Testis-specific protein 57; Translokin
蛋白名称
Centrosomal protein of 57 kDa
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9702
Human Swissprot No.
Q86XR8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q86XR8/entry
Mouse Swissprot No.
Q8CEE0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CEE0
免疫原
The antiserum was produced against synthesized peptide derived from human CEP57. AA range:241-290
特异性
CEP57 Polyclonal Antibody detects endogenous levels of CEP57 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple
细胞定位
Nucleus . Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
功能
function:Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2.,similarity:Belongs to the translokin family.,subcellular location:Associates with microtubules and the centrosome.,subunit:Homodimer. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
