产品名称
CUX1 Rabbit Polyclonal Antibody
别名
CUX1; CUTL1; Homeobox protein cut-like 1; CCAAT displacement protein; CDP; Homeobox protein cux-1; CUX1; CUTL1; Protein CASP
蛋白名称
Homeobox protein cut-like 1/Protein CASP
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1523
Human Swissprot No.
P39880/Q13948
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P39880/entry
Mouse Gene ID
13047/13047
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13047
免疫原
The antiserum was produced against synthesized peptide derived from human CUTL1. AA range:10-59
特异性
CUX1 Polyclonal Antibody detects endogenous levels of CUX1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011],
组织表达
Colon,Duodenum,Liver,Umbilical vein,
功能
alternative products:Additional isoforms seem to exist,function:May be involved in intra-Golgi retrograde transport.,function:Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer.,miscellaneous:Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CASP family.,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 3 CUT DNA-binding domains.,subunit:Homodimer; disulfide-linked. Interacts with GOLGA5.,subunit:Interacts with BANP.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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