产品名称
CDKN3 Rabbit Polyclonal Antibody
别名
CDKN3; CDI1; CIP2; KAP; Cyclin-dependent kinase inhibitor 3; CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase
蛋白名称
Cyclin-dependent kinase inhibitor 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1033
Human Swissprot No.
Q16667
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16667/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72391
Mouse Swissprot No.
Q810P3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q810P3
免疫原
The antiserum was produced against synthesized peptide derived from human CDKN3. AA range:31-80
特异性
CDKN3 Polyclonal Antibody detects endogenous levels of CDKN3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
细胞定位
Cytoplasm, perinuclear region .
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550].,function:May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.,induction:Up-regulated in breast and prostate cancer cells.,similarity:Belongs to the protein-tyrosine phosphatase family.,subunit:Interacts with cyclin-dependent kinases such as CDC2, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
