产品名称
CDKAL1 Rabbit Polyclonal Antibody
别名
CDKAL1; Threonylcarbamoyladenosine tRNA methylthiotransferase; CDK5 regulatory subunit-associated protein 1-like 1; tRNA-t(6)A37 methylthiotransferase
蛋白名称
Threonylcarbamoyladenosine tRNA methylthiotransferase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54901
Human Swissprot No.
Q5VV42
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5VV42/entry
Mouse Swissprot No.
Q91WE6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91WE6
免疫原
The antiserum was produced against synthesized peptide derived from human CDKAL. AA range:10-59
特异性
CDKAL1 Polyclonal Antibody detects endogenous levels of CDKAL1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010],
组织表达
Expressed in pancreatic islets.
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. .
功能
cofactor:Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.,similarity:Belongs to the methylthiotransferase family. CDKAL1 subfamily.,similarity:Contains 1 MTTase N-terminal domain.,similarity:Contains 1 TRAM domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
