产品名称
CdcA7 Rabbit Polyclonal Antibody
别名
CDCA7; JPO1; Cell division cycle-associated protein 7; Protein JPO1
蛋白名称
Cell division cycle-associated protein 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83879
Human Swissprot No.
Q9BWT1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BWT1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66953
Mouse Swissprot No.
Q9D0M2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D0M2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=311742
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4KM91
免疫原
The antiserum was produced against synthesized peptide derived from human CDCA7. AA range:141-190
特异性
CdcA7 Polyclonal Antibody detects endogenous levels of CdcA7 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
cell division cycle associated 7(CDCA7) Homo sapiens This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis.
细胞定位
Nucleus. Cytoplasm. Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.
功能
function:Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.,induction:Activated by MYC and possibly E2F1.,miscellaneous:CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines.,tissue specificity:Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
