产品名称
SATB1 Rabbit Polyclonal Antibody
别名
DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.302% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6304
Human Swissprot No.
Q01826
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01826/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20230
Mouse Swissprot No.
Q60611
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60611
免疫原
Synthesized peptide derived from human SATB1 AA range: 343-393
特异性
This antibody detects endogenous levels of SATB1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016],
组织表达
Expressed predominantly in thymus.
细胞定位
Nucleus matrix . Nucleus, PML body . Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences (PubMed:12692553). When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:18408014). .
功能
function:Binds to DNA at special AT-rich sequences at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA.,PTM:Sumoylated.,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 2 CUT DNA-binding domains.,tissue specificity:Expressed predominantly in thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
