产品名称
Cdc42EP2 Rabbit Polyclonal Antibody
别名
CDC42EP2; BORG1; CEP2; Cdc42 effector protein 2; Binder of Rho GTPases 1
蛋白名称
Cdc42 effector protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10435
Human Swissprot No.
O14613
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14613/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104252
Mouse Swissprot No.
Q8JZX9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8JZX9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=309175
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5PQP4
免疫原
The antiserum was produced against synthesized peptide derived from human BORG1. AA range:10-59
特异性
Cdc42EP2 Polyclonal Antibody detects endogenous levels of Cdc42EP2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011],
组织表达
Highly expressed in the heart. Weakly expressed in the pancreas and liver.
细胞定位
Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
功能
domain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart. Weakly expressed in the pancreas and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
