产品名称
Cdc37 Rabbit Polyclonal Antibody
别名
CDC37; CDC37A; Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37
蛋白名称
Hsp90 co-chaperone Cdc37
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11140
Human Swissprot No.
Q16543
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16543/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12539
Mouse Swissprot No.
Q61081
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61081
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114562
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63692
免疫原
The antiserum was produced against synthesized peptide derived from human CDC37. AA range:1-50
特异性
Cdc37 Polyclonal Antibody detects endogenous levels of Cdc37 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008],
功能
function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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