产品名称
Cdc23 Rabbit Polyclonal Antibody
别名
CDC23; ANAPC8; Cell division cycle protein 23 homolog; Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8
蛋白名称
Cell division cycle protein 23 homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8697
Human Swissprot No.
Q9UJX2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UJX2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=52563
Mouse Swissprot No.
Q8BGZ4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGZ4
免疫原
The antiserum was produced against synthesized peptide derived from human APC8. AA range:251-300
特异性
Cdc23 Polyclonal Antibody detects endogenous levels of Cdc23 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008],
组织表达
Bone marrow,Brain,Duodenum,Epithelium,Pancreas,Placenta,
细胞定位
intracellular,nucleoplasm,anaphase-promoting complex,cytosol,
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;
功能
function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Thr-556 occurs specifically during mitosis.,similarity:Belongs to the APC8/CDC23 family.,similarity:Contains 9 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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