产品名称
CD9 Rabbit Polyclonal Antibody
别名
CD9; MIC3; TSPAN29; GIG2; CD9 antigen; 5H9 antigen; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29; p24; CD antigen CD9
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=928
Human Swissprot No.
P21926
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P21926/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12527
Mouse Swissprot No.
P40240
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P40240
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24936
Rat Swissprot Link
http://www.uniprot.org/uniprot/P40241
免疫原
The antiserum was produced against synthesized peptide derived from human CD9. AA range:101-150
特异性
CD9 Polyclonal Antibody detects endogenous levels of CD9 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011],
组织表达
Detected in platelets (at protein level) (PubMed:19640571). Expressed by a variety of hematopoietic and epithelial cells (PubMed:19640571).
细胞定位
Cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Secreted, extracellular exosome . Present at the cell surface of oocytes. Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO. .
信号通路
Hematopoietic cell lineage;
功能
function:Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.,PTM:Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.,similarity:Belongs to the tetraspanin (TM4SF) family.,subunit:Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.,tissue specificity:Expressed by a variety of hematopoietic and epithelial cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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