产品名称
TRPV2 Rabbit Polyclonal Antibody
别名
Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.305% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51393
Human Swissprot No.
Q9Y5S1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y5S1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22368
Mouse Swissprot No.
Q9WTR1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTR1
Rat Gene Link
https://www.uniprot.org/uniprot/29465
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WUD2
免疫原
Synthesized peptide derived from human TRPV2 AA range: 493-543
特异性
This antibody detects endogenous levels of TRPV2 at Human/Mouse/Rat
稀释度
WB 1:500-2000; IF ICC 1:100-500;IP 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008],
组织表达
Brain,Lymphoblast,Skin,
细胞定位
Cell membrane ; Multi-pass membrane protein . Cytoplasm . Melanosome . Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
功能
function:Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.,PTM:N-glycosylated.,PTM:Phosphorylated by PKA.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 6 ANK repeats.,subcellular location:Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
