产品名称
CD32-A Rabbit Polyclonal Antibody
别名
FCGR2A; CD32; FCG2; FCGR2A1; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD antigen CD32
蛋白名称
Low affinity immunoglobulin gamma Fc region receptor II-a
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2212
Human Swissprot No.
P12318
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P12318/entry
免疫原
The antiserum was produced against synthesized peptide derived from human FCGR2A. AA range:241-290
特异性
CD32-A Polyclonal Antibody detects endogenous levels of CD32-A protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Fc fragment of IgG receptor IIa(FCGR2A) Homo sapiens This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008],
组织表达
Found on monocytes, neutrophils and eosinophil platelets.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
信号通路
Fc gamma R-mediated phagocytosis;Systemic lupus erythematosus;
功能
function:Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function.,tissue specificity:Found on monocytes, neutrophils and eosinophil platelets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
