产品名称
ISG20 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3669
Human Swissprot No.
Q96AZ6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96AZ6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/57444
Mouse Swissprot No.
Q9JL16
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JL16
免疫原
Synthesized peptide derived from human ISG20 AA range: 87-137
特异性
This antibody detects endogenous levels of ISG20 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines.
细胞定位
Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
功能
catalytic activity:Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.,cofactor:Manganese.,function:Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.,induction:Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level.,miscellaneous:Stable and constitutive expression confers resistance to vesicular stomatitis virus (VSV), influenza virus, and encephalomyocarditis virus (EMCV) infection in HeLa cells, providing an alternative antiviral pathway against RNA genomic viruses. Up regulated by E2 in estrogen receptor-positive breast cancer lines.,similarity:Belongs to the exonuclease superfamily.,subunit:Associates with PML and SP100 in the PML NB complex.,tissue specificity:Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
