BD-PT0750

CD30-L Rabbit Polyclonal Antibody

TNFSF8; CD30L; CD30LG; Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; CD antigen CD153

常规抗体

TNFSF8

Tumor necrosis factor ligand superfamily member 8

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2965

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2965

P32971

http://www.uniprot.org/uniprotkb/P32971/entry

21949

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21949

P32972

http://www.uniprot.org/uniprot/P32972

The antiserum was produced against synthesized peptide derived from human CD153. AA range:71-120

CD30-L Polyclonal Antibody detects endogenous levels of CD30-L protein.

WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

30kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

Brain,Thymus,

Membrane; Single-pass type II membrane protein.

Cytokine-cytokine receptor interaction;

function:Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.