产品名称
CD307 Rabbit Polyclonal Antibody
别名
FCRL5; FCRH5; IRTA2; Fc receptor-like protein 5; FcR-like protein 5; FcRL5; BXMAS1; Fc receptor homolog 5; FcRH5; Immune receptor translocation-associated protein 2; CD antigen CD307e
蛋白名称
Fc receptor-like protein 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83416
Human Swissprot No.
Q96RD9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96RD9/entry
Mouse Swissprot No.
Q68SN8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q68SN8
免疫原
The antiserum was produced against synthesized peptide derived from human FCRL5. AA range:281-330
特异性
CD307 Polyclonal Antibody detects endogenous levels of CD307 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010],
组织表达
Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
disease:A chromosomal aberration involving FCRL5 is found in Burkitt lymphoma (BL) cell lines with 1q21 abnormalities [MIM:113970]. Duplication dup(1)(q21q32).,domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).,function:May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.,similarity:Contains 8 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B cells and down-regulated in germinal center cells (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
