产品名称
CD272 Rabbit Polyclonal Antibody
别名
BTLA; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD antigen CD272
蛋白名称
B- and T-lymphocyte attenuator
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=151888
Human Swissprot No.
Q7Z6A9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q7Z6A9/entry
Mouse Swissprot No.
Q7TSA3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TSA3
免疫原
Synthetic peptide from human protein at AA range: 101-150
特异性
CD272 Polyclonal Antibody detects endogenous levels of CD272 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011],
组织表达
PCR rescued clones,Peripheral blood,Thymus,Trachea,
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
function:Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.,PTM:N-glycosylated.,PTM:Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
