BD-PT0741

CD24 Rabbit Polyclonal Antibody

CD24; CD24A; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD antigen CD24

常规抗体

CD24

Signal transducer CD24

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

100133941

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100133941

P25063

http://www.uniprot.org/uniprotkb/P25063/entry

12484

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12484

P24807

http://www.uniprot.org/uniprot/P24807

25145

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25145

Q07490

http://www.uniprot.org/uniprot/Q07490

The antiserum was produced against synthesized peptide derived from human CD24. AA range:14-63

CD24 Polyclonal Antibody detects endogenous levels of CD24 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

35,45kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],

B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

Cell membrane; Lipid-anchor, GPI-anchor.

disease:Genetic variations in CD24 are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.,function:Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.,induction:Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.,PTM:Extensively O-glycosylated.,similarity:Belongs to the CD24 family.,subunit:Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma.,tissue specificity:B-cells. Expressed in a number of B-cell lines including P32/SH and Nawalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.