产品名称
SC23A Rabbit Polyclonal Antibody
别名
Protein transport protein Sec23A (SEC23-related protein A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.308% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10484
Human Swissprot No.
Q15436
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15436/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20334
Mouse Swissprot No.
Q01405
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q01405
免疫原
Synthesized peptide derived from human SC23A AA range: 352-402
特异性
This antibody detects endogenous levels of SC23A at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Enriched at endoplasmic reticulum exit sites, also known as transitional endoplasmic reticulum (tER). .
功能
disease:Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:607812]. Cranio-lenticulo-sutural dysplasia (CLSD) is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.,function:Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.,similarity:Belongs to the SEC23/SEC24 family. SEC23 subfamily.,subcellular location:In the ribosome-free transitional face of the ER and associated vesicles.,subunit:COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4 (By similarity). Interacts with SEC16A.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
