产品名称
CD179b Rabbit Polyclonal Antibody
别名
IGLL1; IGL1; Immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD antigen CD179b; IGLC1; Ig lambda-1 chain C regions; IGLC2; Ig
基因名称
IGLL1/IGLC1/IGLC2/IGLC3/IGLC6/IGLC7
蛋白名称
Immunoglobulin lambda-like polypeptide 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3543
Human Swissprot No.
P15814/P0CG04/P0CG05/P0CG06/P0CF74/A0M8Q6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P15814/entry
免疫原
The antiserum was produced against synthesized peptide derived from human CD179b. AA range:26-75
特异性
CD179b Polyclonal Antibody detects endogenous levels of CD179b protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
immunoglobulin lambda like polypeptide 1(IGLL1) Homo sapiens The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).
细胞定位
Endoplasmic reticulum . Secreted . In pre-B cells, localizes predominantly to the endoplasmic reticulum. .
信号通路
Primary immunodeficiency;
功能
disease:Defects in IGLL1 are a cause of autosomal recessive non-Bruton type agammaglobulinemia [MIM:601495]. It is characterized by agammaglobulinemia and markedly reduced numbers of B cells.,online information:IGLL1 mutation db,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Associates non-covalently with VPREB1.,tissue specificity:Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
