产品名称
CD137L Rabbit Polyclonal Antibody
别名
TNFSF9; Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL
蛋白名称
Tumor necrosis factor ligand superfamily member 9
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8744
Human Swissprot No.
P41273
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P41273/entry
Mouse Swissprot No.
P41274
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P41274
免疫原
The antiserum was produced against synthesized peptide derived from human TNFSF9. AA range:31-80
特异性
CD137L Polyclonal Antibody detects endogenous levels of CD137L protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided b
组织表达
Expressed in brain, placenta, lung, skeletal muscle and kidney.
细胞定位
Membrane; Single-pass type II membrane protein.
信号通路
Cytokine-cytokine receptor interaction;
功能
function:Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer .,tissue specificity:Expressed in brain, placenta, lung, skeletal muscle and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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