产品名称
CD137 Rabbit Polyclonal Antibody
别名
TNFRSF9; CD137; ILA; Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD antigen CD137
蛋白名称
Tumor necrosis factor receptor superfamily member 9
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3604
Human Swissprot No.
Q07011
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q07011/entry
Mouse Swissprot No.
P20334
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P20334
免疫原
The antiserum was produced against synthesized peptide derived from human TNFRSF9. AA range:101-150
特异性
CD137 Polyclonal Antibody detects endogenous levels of CD137 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008],
组织表达
Expressed on the surface of activated T-cells.
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Cytokine-cytokine receptor interaction;
功能
function:Receptor for TNFSF14/4-1BBL. Possibly active during T cell activation.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.,tissue specificity:Expressed on the surface of activated T-cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
