产品名称
CCRL1 Rabbit Polyclonal Antibody
别名
CCRL1; CCBP2; CCR11; VSHK1; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKR
蛋白名称
C-C chemokine receptor type 11
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51554
Human Swissprot No.
Q9NPB9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NPB9/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=252837
Mouse Swissprot No.
Q924I3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q924I3
免疫原
The antiserum was produced against synthesized peptide derived from human CCRL1. AA range:291-340
特异性
CCRL1 Polyclonal Antibody detects endogenous levels of CCRL1 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013],
组织表达
Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
细胞定位
Early endosome . Recycling endosome . Cell membrane ; Multi-pass membrane protein . Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
功能
function:Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
