产品名称
CCK-AR Rabbit Polyclonal Antibody
别名
CCKAR; CCKRA; Cholecystokinin receptor type A; CCK-A receptor; CCK-AR; Cholecystokinin-1 receptor; CCK1-R
蛋白名称
Cholecystokinin receptor type A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=886
Human Swissprot No.
P32238
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P32238/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12425
Mouse Swissprot No.
O08786
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08786
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24889
Rat Swissprot Link
http://www.uniprot.org/uniprot/P30551
免疫原
The antiserum was produced against synthesized peptide derived from human CCKAR. AA range:215-264
特异性
CCK-AR Polyclonal Antibody detects endogenous levels of CCK-AR protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008],
组织表达
Gall bladder,Peripheral blood leukocyte,Stomach,
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;
功能
function:Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Cholecystokinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
