产品名称
CBP80 Rabbit Polyclonal Antibody
别名
NCBP1; CBP80; NCBP; Nuclear cap-binding protein subunit 1; 80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit
蛋白名称
Nuclear cap-binding protein subunit 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4686
Human Swissprot No.
Q09161
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q09161/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=433702
Mouse Swissprot No.
Q3UYV9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UYV9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=298075
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q56A27
免疫原
The antiserum was produced against synthesized peptide derived from human NCBP1. AA range:1-50
特异性
CBP80 Polyclonal Antibody detects endogenous levels of CBP80 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008],
组织表达
Brain,Epithelium,Placenta,
细胞定位
Nucleus . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
功能
function:Involved in mediating U snRNA export from the nucleus. Binds to 5' capped mRNA.,similarity:Belongs to the NCBP1 family.,similarity:Contains 1 MIF4G domain.,subunit:Found in a U snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX (By similarity). Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
