产品名称
ZNT5 Rabbit Polyclonal Antibody
别名
Zinc transporter 5 (ZnT-5) (Solute carrier family 30 member 5) (ZnT-like transporter 1) (hZTL1)
基因名称
SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.311% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64924
Human Swissprot No.
Q8TAD4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TAD4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/69048
Mouse Swissprot No.
Q8R4H9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R4H9
免疫原
Synthesized peptide derived from human ZNT5 AA range: 106-156
特异性
This antibody detects endogenous levels of ZNT5 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011],
组织表达
Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.
功能
function:Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.,induction:Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.,miscellaneous:The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP.,similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.,subcellular location:Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.,subunit:Heterooligomer. Interacts with ZNT6.,tissue specificity:Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
