产品名称
ABCB9 Rabbit Polyclonal Antibody
别名
ATP-binding cassette sub-family B member 9 (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.312% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23457
Human Swissprot No.
Q9NP78
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NP78/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56325
Mouse Swissprot No.
Q9JJ59
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJ59
Rat Gene Link
https://www.uniprot.org/uniprot/63886
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QYJ4
免疫原
Synthesized peptide derived from human ABCB9 AA range: 224-274
特异性
This antibody detects endogenous levels of ABCB9 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011],
组织表达
Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.
细胞定位
Lysosome membrane ; Multi-pass membrane protein . May be located in membrane rafts. Takes an intracellular route from the endoplasmic reticulum (ER), via Golgi and early endosomes to late endosomal and lysosomal compartments (PubMed:30877195). .
功能
function:May function as a peptide transporter.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. MHC peptide exporter (TC 3.A.1.209) subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Homodimer or heterodimer .,tissue specificity:Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
