BD-PT0678

Catenin-γ Rabbit Polyclonal Antibody

JUP; CTNNG; DP3; Junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3

常规抗体

JUP

Junction plakoglobin

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3728

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3728

P14923

http://www.uniprot.org/uniprotkb/P14923/entry

16480

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16480

Q02257

http://www.uniprot.org/uniprot/Q02257

81679

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81679

Q6P0K8

http://www.uniprot.org/uniprot/Q6P0K8

The antiserum was produced against synthesized peptide derived from human Catenin-gamma. AA range:696-745

Catenin-γ Polyclonal Antibody detects endogenous levels of Catenin-γ protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

82kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008],

Cervix carcinoma,Epidermal carcinoma,Epithelium,Leukocyte,Lung,Lung carcinoma,Place

Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form.

Pathways in cancer;Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);

disease:Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy type 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,disease:Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.,function:Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the beta-catenin family.,similarity:Contains 9 ARM repeats.,subcellular location:Cytoplasmic in a soluble and membrane-associated form.,subunit:Homodimer. Interacts with MUC1.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.