产品名称
Caspase12 Rabbit Polyclonal Antibody
别名
CASP12; Inactive caspase-12; CASP-12
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=120329
Human Swissprot No.
Q6UXS9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6UXS9/entry
Mouse Swissprot No.
O08736
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08736
免疫原
The antiserum was produced against synthesized peptide derived from human Caspase12. AA range:50-99
特异性
Caspase12 Polyclonal Antibody detects endogenous levels of Caspase12 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011],
组织表达
Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
细胞定位
endoplasmic reticulum,IPAF inflammasome complex,NLRP3 inflammasome complex,AIM2 inflammasome complex,
功能
proteolysis,?apoptosis,?virus-infected cell apoptosis,?ER-nuclear signaling pathway,?response to unfolded protein,?cell death,?response to organic substance,?regulation of cell death,?programmed cell death,?death,?endoplasmic reticulum unfolded protein response,?cellular response to stress,?cellular response to unfolded protein,?response to endoplasmic reticulum stress,?regulation of apoptosis,?regulation of programmed cell death,?response to protein stimulus,apoptosis in response to endoplasmic reticulum stress,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
