BD-PT0650

Casein Kinase Iδ Rabbit Polyclonal Antibody

CSNK1D; HCKID; Casein kinase I isoform delta; CKI-delta; CKId; Tau-protein kinase CSNK1D

常规抗体

CSNK1D

Casein kinase I isoform delta

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1453

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1453

P48730

http://www.uniprot.org/uniprotkb/P48730/entry

104318

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104318

Q9DC28

http://www.uniprot.org/uniprot/Q9DC28

64462

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64462

Q06486

http://www.uniprot.org/uniprot/Q06486

The antiserum was produced against synthesized peptide derived from human CSNK1D. AA range:291-340

Casein Kinase Iδ Polyclonal Antibody detects endogenous levels of Casein Kinase Iδ protein.

WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

47kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014],

Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.

Hedgehog;Gap junction;Circadian rhythm;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.,enzyme regulation:Exhibits substrate-dependent heparin activation.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.,PTM:Autophosphorylated on serine and threonine residues.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation.,tissue specificity:Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopioetic cells and mature granulocytes. Also found in monocytes and lymphocytes.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.